Nicole Golob-Schwarzl

Psoriasis is a chronic, immune-mediated, inflammatory skin disease, which affects humans worldwide. Protein synthesis can be divided into four steps: initiation, elongation, termination and ribosome recycling. The step of initiation is assigned as rate limiting step in protein synthesis and is regulated by eIFs. eIFs are major targets for various therapies and are functionally linked to the PI3K/Akt/mTOR pathway. The main goal of this research theme comprises the investigation of the direct and indirect effects of eIFs, both in pre-clinical models and psoriasis patients, to further determine their mechanistic action in psoriasis and as direct targets for anti-psoriatic treatment.

I did my undergraduate studies in Biochemistry and Molecular Biomedicine (Master) at the Technical University of Graz, Austria. After stays abroad at the Erasmus Hogeschool, Brussels, Belgium, and the National Institute of Health, Washington, USA, she started her PhD in Molecular Medicine and Inflammation at the Medical University Graz, Austria. During her PhD, she investigated the role of PI3K/AKT/mTOR pathway members and eIFs in hepatocellular carcinoma and colorectal cancer at the Department of Pathology, Medical University Graz, Austria. In December 2018, she joined Prof. Wolf´s group as a postdoc, studying the potential role of eIFs as therapeutic targets in psoriasis

nicole.golob(at)medunigraz.at

ORCID: 0000-0002-7330-1854